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1

Total Synthesis and Antitumor Activity of ZK-EPO: The First Fully Synthetic Epothilone in Clinical Development

Ulrich Klar, Bernd Buchmann, Wolfgang Schwede, Werner Skuballa, Jens Hoffmann, Rosemarie B. Lichtner

Journal:

Angewandte Chemie

Year:

2006

Language:

english

File:

PDF, 600 KB

english, 2006

2

Total Synthesis and Antitumor Activity of ZK-EPO: The First Fully Synthetic Epothilone in Clinical Development

Ulrich Klar, Bernd Buchmann, Wolfgang Schwede, Werner Skuballa, Jens Hoffmann, Rosemarie B. Lichtner

Journal:

Angewandte Chemie International Edition

Year:

2006

Language:

english

File:

PDF, 601 KB

english, 2006

3

Ein neuer Weg zu 6a-Carbacyclinen – Synthese eines stabilen, biologisch potenten Prostacyclin-Analogons

Dr. Werner Skuballa, Prof. Dr. Helmut Vorbrüggen

Journal:

Angewandte Chemie

Year:

1981

Language:

german

File:

PDF, 222 KB

german, 1981

4

Von Rigidität zu konformativer Flexibilität: makrocyclische Template, abgeleitet von Ansa-Steroiden

Stefan Bäurle, Thorsten Blume, Anne Mengel, Christian Parchmann, Werner Skuballa, Siegfried Bäsler, Martina Schäfer, Detlev Sülzle, Hans-Peter Wrona-Metzinger

Journal:

Angewandte Chemie

Year:

2003

Language:

german

File:

PDF, 147 KB

german, 2003

5

Titelbild: Total Synthesis and Antitumor Activity of ZK-EPO: The First Fully Synthetic Epothilone in Clinical Development (Angew. Chem. 47/2006)

Ulrich Klar, Bernd Buchmann, Wolfgang Schwede, Werner Skuballa, Jens Hoffmann, Rosemarie B. Lichtner

Journal:

Angewandte Chemie

Year:

2006

Language:

german

File:

PDF, 161 KB

german, 2006

6

A New Route to 6a-Carbacyclins–Synthesis of a Stable, Biologically Potent Prostacyclin Analogue

Dr. Werner Skuballa, Prof. Dr. Helmut Vorbrüggen

Journal:

Angewandte Chemie International Edition

Year:

1981

Language:

english

File:

PDF, 336 KB

english, 1981

7

From Rigidity to Conformational Flexibility: Macrocyclic Templates Derived from ansa-Steroids

Stefan Bäurle, Thorsten Blume, Anne Mengel, Christian Parchmann, Werner Skuballa, Siegfried Bäsler, Martina Schäfer, Detlev Sülzle, Hans-Peter Wrona-Metzinger

Journal:

Angewandte Chemie International Edition

Year:

2003

Language:

english

File:

PDF, 147 KB

english, 2003

8

Cover Picture: Total Synthesis and Antitumor Activity of ZK-EPO: The First Fully Synthetic Epothilone in Clinical Development (Angew. Chem. Int. Ed. 47/2006)

Ulrich Klar, Bernd Buchmann, Wolfgang Schwede, Werner Skuballa, Jens Hoffmann, Rosemarie B. Lichtner

Journal:

Angewandte Chemie International Edition

Year:

2006

Language:

english

File:

PDF, 161 KB

english, 2006

9

Polyacetylenverbindungen, 175. Synthese und Biogenese von Anthemis-Thioäthern

Ferdinand Bohlmann, Werner Skuballa

Journal:

European Journal of Inorganic Chemistry

Year:

1970

File:

PDF, 357 KB

1970

10

Polyacetylenverbindungen, 199. Synthese der Enolätherpolyine aus Gnaphalium-Arten

Ferdinand Bohlmann, Werner Skuballa

Journal:

European Journal of Inorganic Chemistry

Year:

1971

Language:

german

File:

PDF, 247 KB

german, 1971

11

Polyacetylenverbindungen, 2131) Neuartige natürliche Schwefelacetylen-Verbindungen

Ferdinand Bohlmann, Werner Skuballa

Journal:

European Journal of Inorganic Chemistry

Year:

1973

Language:

german

File:

PDF, 365 KB

german, 1973

12

Notiz über die Umwandlung von Allylalkoholen in Kohlenwasserstoffe

Ferdinand Bohlmann, Jürgen Staffeldt, Werner Skuballa

Journal:

European Journal of Inorganic Chemistry

Year:

1976

Language:

german

File:

PDF, 171 KB

german, 1976

13

ChemInform Abstract: Synthesis and Biological Activity of Leukotriene Derivatives

Stefan Jaroch, Bernd Buchmann, Werner Skuballa

Journal:

Year:

2000

File:

PDF, 24 KB

2000

14

ChemInform Abstract: Synthesis and Biological Activity of Epothilones

Ulrich Klar, Werner Skuballa, Bernd Buchmann, Wolfgang Schwede, Thomas Bunte, Jens Hoffmann, Rosemarie B. Lichtner

Journal:

Year:

2002

File:

PDF, 24 KB

2002

15

Design and Synthesis of Macrocyclic Inhibitors of Phosphatase Cdc25B.

Stefan Baeurle, Thorsten Blume, Judith Guenther, Daniela Henschel, Roman C. Hillig, Manfred Husemann, Anne Mengel, Christian Parchmann, Elke Schmid, Werner Skuballa

Journal:

Year:

2004

Language:

english

File:

PDF, 128 KB

english, 2004

16

Assignment of the 5,6-Double-Bond Configuration in Iloprost and Isoiloprost from 13C-NMR Shifts Determined by 2D Methods

Kurt V. Schenker, Wolfgang Von Philipsborn, C. Anderson Evans, Werner Skuballa, Georg-Alexander Hoyer

Journal:

Helvetica Chimica Acta

Year:

1986

Language:

english

File:

PDF, 461 KB

english, 1986

17

Polyacetylenverbindungen, 187. Über eine neue Photoreaktion von Polyinenen und ein Cyclopropan-Derivat aus Centaurea ruthenica Lam.

Ferdinand Bohlmann, Werner Skuballa, Christa Zdero, Thomas Kühle, Peter Steirl

Journal:

European Journal of Organic Chemistry

Year:

1971

Language:

german

File:

PDF, 782 KB

german, 1971

18

Mikrobiologische und Enzymatische Reaktionsstufen in der Synthese von Prostacyclin-Analoga

Karl Petzoldt, Helmut Dahl, Werner Skuballa, Matthias Gottwald

Journal:

European Journal of Organic Chemistry

Year:

1990

Language:

german

File:

PDF, 525 KB

german, 1990

19

Design and synthesis of macrocyclic inhibitors of phosphatase Cdc25B

Stefan Bäurle, Thorsten Blume, Judith Günther, Daniela Henschel, Roman C. Hillig, Manfred Husemann, Anne Mengel, Christian Parchmann, Elke Schmid, Werner Skuballa

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 260 KB

english, 2004

20

Discovery of quinolines as selective glucocorticoid receptor agonists

Stefan Jaroch, Markus Berger, Christoph Huwe, Konrad Krolikiewicz, Hartmut Rehwinkel, Heike Schäcke, Norbert Schmees, Werner Skuballa

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 226 KB

english, 2010

21

The identification of a small molecule inhibitor that specifically reduces T cell-mediated adaptive but not LPS-mediated innate immunity by T cell membrane–monocyte contact bioassay

Yi-Yang Yvonne Li, Ming Bao, Janet Meurer, Werner Skuballa, John G. Bauman, Wolf-Dietrich Doecke, Thomas M. Zollner

Journal:

Immunology Letters

Year:

2008

Language:

english

File:

PDF, 327 KB

english, 2008

22

Novel macrocyclic templates by ring enlargement of ansa-steroids

Stefan Bäurle, Thorsten Blume, Emmanuel Leroy, Anne Mengel, Christian Parchmann, Kathrin Schmidt, Werner Skuballa

Journal:

Tetrahedron Letters

Year:

2004

Language:

english

File:

PDF, 259 KB

english, 2004

23

Synthesis of 6,9-homo-prostacyclin a stable prostacyclin analog

Werner Skuballa

Journal:

Tetrahedron Letters

Year:

1980

Language:

english

File:

PDF, 261 KB

english, 1980

24

Synthesis of prostacyclin analogs stabilized by acceptor substituents at the 5-position

Werner Skuballa, Bernd Radüchel, Helmut Vorbrüggen

Journal:

Tetrahedron Letters

Year:

1988

Language:

english

File:

PDF, 278 KB

english, 1988

25

In vitro effects of PGF2α and a metabolically stable derivative on 20α-hydroxysteroid-dehydrogenase activity in corpora lutea isolated from pseudopregnant rat ovaries

Nelson Brambaifa, Werner Skuballa, Ekkehard Schillinger

Journal:

Prostaglandins, Leukotrienes and Medicine

Year:

1984

Language:

english

File:

PDF, 603 KB

english, 1984

26

Novel 3-Oxa Lipoxin A 4 Analogues with Enhanced Chemical and Metabolic Stability Have Anti-inflammatory Activity in Vivo

Guilford, William J., Bauman, John G., Skuballa, Werner, Bauer, Shawn, Wei, Guo Ping, Davey, David, Schaefer, Caralee, Mallari, Cornell, Terkelsen, Jennifer, Tseng, Jih-Lie, Shen, Jun, Subramanyam, Ba

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 298 KB

english, 2004

27

SAGOPILONE, A NOVEL EPOTHILONE, INHIBITS TUMOR CELL GROWTH IN PRECLINICAL MODELS OF UROLOGICAL CANCER

Winsel, Sebastian, Hammer, Stefanie, Buchmann, Bernd, Schwede, Wolfgang, Skuballa, Werner, Siemeister, Gerhard, Klar, Ulrich, Hoffmann, Jens

Journal:

The Journal of Urology

Year:

2008

Language:

english

File:

PDF, 124 KB

english, 2008

28

The guinea pig as a suitable species for the characterization of the LTB4 receptor antagonist ZK 158252

Giesen, Claudia, Buchmann, Bernd, Ekerdt, Roland, Fröhlich, Wolfgang, Heindl, Josef, Skuballa, Werner

Journal:

Journal of Dermatological Science

Year:

1998

Language:

english

File:

PDF, 180 KB

english, 1998

29

Efficient Chiral Pool Synthesis of the C1-C6 Fragment of Epothilones

Klar, Ulrich, Röhr, Bodo, Kuczynski, Frank, Schwede, Wolfgang, Berger, Markus, Skuballa, Werner, Buchmann, Bernd

Journal:

Year:

2005

Language:

english

File:

PDF, 1015 KB

english, 2005

30

ChemInform Abstract: POLYACETYLENVERBINDUNGEN 187. MITT. NEUE PHOTORK. VON POLYINENEN UND EIN CYCLOPROPAN-DERIVAT AUS CENTAUREA RUTHENICA LAM.

BOHLMANN, FERDINAND, SKUBALLA, WERNER, ZDERO, CHRISTA, KUEHLE, THOMAS, STEIRL, PETER

Journal:

Chemischer Informationsdienst. Organische Chemie

Year:

1971

Language:

german

File:

PDF, 352 KB

german, 1971

31

ChemInform Abstract: POLYACETYLENVERBINDUNGEN 213. MITT. NEUARTIGE NATUERLICHE SCHWEFELACETYLEN-VERBINDUNGEN

BOHLMANN, FERDINAND, SKUBALLA, WERNER

Journal:

Chemischer Informationsdienst

Year:

1973

File:

PDF, 100 KB

1973

32

ChemInform Abstract: TRANSFORMATION OF ALLYL ALCOHOLS INTO HYDROCARBONS

BOHLMANN, FERDINAND, STAFFELDT, JUERGEN, SKUBALLA, WERNER

Journal:

Chemischer Informationsdienst

Year:

1976

File:

PDF, 214 KB

1976

33

ChemInform Abstract: POLYACETYLENVERBINDUNGEN 175. MITT. SYNTH. UND BIOGENESE VON ANTHEMIS-THIOAETHERN

BOHLMANN, FERDINAND, SKUBALLA, WERNER

Journal:

Chemischer Informationsdienst. Organische Chemie

Year:

1970

File:

PDF, 154 KB

1970

34

ChemInform Abstract: POLYACETYLENVERBINDUNGEN 199. MITT. SYNTH. DER ENOLAETHERPOLYINE AUS GNAPHALIUM-ARTEN

BOHLMANN, FERDINAND, SKUBALLA, WERNER

Journal:

Chemischer Informationsdienst. Organische Chemie

Year:

1971

File:

PDF, 210 KB

1971

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